Title: METABOLISM OF METHIONINE IN WOMEN USING ORAL CONTRACEPTIVES Abstract approved:
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Serum vitamin A status in women users of lowdose oral contraceptives and in postmenopausal women taking hormone replacement therapy.
Background: One of the most important nonenzymatic antioxidant defense systems is vitamin A, and is considered as an important dietary agent for reducing cardiovascular diseases. Objective: The objective of this study was to investigate the serum vitamin A status in women who used low-dose oral contraceptives (OCs) containing 0.15 mg levonorgestrol and 0.03 mg ethinyl estradiol and also in...
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SUMMARY Cardiovascular complication of oral contraceptives Mohammad Reza Afraz M.D. cardiologist Assistant professor, Gilan university of medical sciences, Rasht. Soon after the introduction of oral contraceptive agents in 1960, the potential risks of cardiovascular disease became apparent. Most investigators agree that there is an increased incidence of hypertension, myocardial infarction, c...
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Background and objectives: Hypericum perforatum L., commonly known as St. John’s wort (SJW) from the family Hypericaceae is a famous medicinal plant used to treat mild to moderate depression; so, it might affect the pharmacokinetics of numerous drugs. Due to widespread herb-drug interactions of SJW, this study was designed to review the clinical evidences regarding the...
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Women using oral contraceptives of the combined oestrogen-progestogen type excrete elevated levels of a number of metabolites of the tryptophan-nicotinic acid ribonucleotide metabolic pathway in urine collected after an oral dose of the amino acid. Increased excretions of Nl-methylnicotinamide reflect an enhanced capacity for the conversion of Ltryptophan to nicotinic acid derivatives, although...
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BACKGROUND There is relevant between individual variability in paracetamol clearance in young women. In this pooled study, we focused on the population pharmacokinetic profile of intravenous paracetamol metabolism and its covariates in young women. METHODS Population PK parameters using non-linear mixed effect modelling were estimated in a pooled dataset of plasma and urine PK studies in 69 y...
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